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Jacqueline Seymour, Health Coach

Jacqueline Seymour

Health Coach

Reviewed By

 Dr. Frank Lipman sits on a chair, cross-legged, arm resting on the back of the chair, lightly touching his other hand that is resting on his thigh. He is wearing blue denim, a blue dress shirt and a navy textured blazer and black glasses. He is smiling, showing his front teeth looking off to the side.

Dr. Frank Lipman

Chief Medical Officer at THE WELL

Published: 05/07/2025

Creatine is well-known for its role in muscle energy and athletic performance, but emerging research shows it also has cognitive benefits—especially when sleep is lacking. Here’s how creatine can support brain function after a poor night’s sleep.

How sleep deprivation affects the brain

When you don’t get enough sleep, your brain struggles with cognitive tasks like memory, focus, and problem-solving. Energy stores in brain cells become depleted, leading to sluggish mental performance.

Creatine: a brain energy booster

Creatine helps produce adenosine triphosphate (ATP), the primary energy source for cells, including brain cells. Research suggests that supplementing with creatine can:‍

Does creatine work after a bad night’s sleep?

Studies indicate that creatine supplementation can help offset some of the negative cognitive effects of sleep deprivation. It won’t fully replace sleep (and definitely is not an excuse to not prioritize sleep) but it may help you stay sharper and more alert when running on fewer hours of rest.

How to use creatine for brain health

  • Dosage: 3-5g per day is typically recommended for cognitive benefits.
  • Timing: Taking it in the morning or before a mentally demanding task may be helpful.
  • Sources: Creatine monohydrate is the most researched and effective form.

If you often deal with poor sleep, creatine can be a valuable tool to support brain function. But remember, prioritizing quality sleep should always be the main goal for long-term cognitive health and longevity. So if you struggle, read “To Sleep Better Tonight, Avoid These 10 Sleep Mistakes”.

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